rt.stan

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/**
 * Reproduction Number (Rt) Functions
 *
 * This group of functions handles the calculation, updating, and conversion of
 * reproduction numbers in the model. The reproduction number represents the average
 * number of secondary infections caused by a single infected individual.
 *
 * @ingroup rt_estimation
 */
 
/**
 * @ingroup rt_estimation
 * @brief Update a vector of effective reproduction numbers (Rt) based on
 * an intercept, breakpoints (i.e. a random walk), and a Gaussian
 * process.
 *
 * @param t Length of the time series
 * @param R0 Initial reproduction number
 * @param noise Vector of Gaussian process noise values
 * @param bps Array of breakpoint indices
 * @param bp_effects Vector of breakpoint effects
 * @param stationary Whether the Gaussian process is stationary (1) or non-stationary (0)
 * @return A vector of length t containing the updated Rt values
 */
vector update_Rt(int t, real R0, vector noise, array[] int bps,
                 vector bp_effects, int stationary) {
  // define control parameters
  int bp_n = num_elements(bp_effects);
  int gp_n = num_elements(noise);
  // initialise intercept
  vector[t] logR = rep_vector(log(R0), t);
  //initialise breakpoints + rw
  if (bp_n) {
    vector[bp_n + 1] bp0;
    bp0[1] = 0;
    bp0[2:(bp_n + 1)] = cumulative_sum(bp_effects);
    logR = logR + bp0[bps];
  }
  //initialise gaussian process
  if (gp_n) {
    vector[t] gp = rep_vector(0, t);
    if (stationary) {
      gp[1:gp_n] = noise;
      // fix future gp based on last estimated
      if (t > gp_n) {
        gp[(gp_n + 1):t] = rep_vector(noise[gp_n], t - gp_n);
      }
    } else {
      gp[2:(gp_n + 1)] = noise;
      gp = cumulative_sum(gp);
    }
    logR = logR + gp;
  }
 
  return exp(logR);
}
 
/**
 * Calculate the log-probability of the reproduction number (Rt) priors
 *
 * This function adds the log density contributions from priors on initial infections
 * and breakpoint effects to the target.
 *
 * @param initial_infections_scale Array of initial infection values
 * @param bp_effects Vector of breakpoint effects
 * @param bp_sd Array of breakpoint standard deviations
 * @param bp_n Number of breakpoints
 * @param cases Array of observed case counts
 * @param initial_infections_guess Initial guess for infections based on cases
 *
 * @ingroup rt_estimation
 */
void rt_lp(array[] real initial_infections_scale, vector bp_effects,
           array[] real bp_sd, int bp_n, array[] int cases,
           real initial_infections_guess) {
  //breakpoint effects on Rt
  if (bp_n > 0) {
    bp_sd[1] ~ normal(0, 0.1) T[0,];
    bp_effects ~ normal(0, bp_sd[1]);
  }
  initial_infections_scale ~ normal(initial_infections_guess, 2);
}
 
/**
 * Helper function for calculating r from R using Newton's method
 *
 * This function performs a single Newton step in the iterative calculation
 * of the growth rate r from the reproduction number R.
 *
 * Code is based on Julia code from
 * https://github.com/CDCgov/Rt-without-renewal/blob/d6344cc6e451e3e6c4188e4984247f890ae60795/EpiAware/test/predictive_checking/fast_approx_for_r.jl
 * under Apache license 2.0.
 *
 * @param R Reproduction number
 * @param r Current estimate of the growth rate
 * @param pmf Generation time probability mass function (first index: 0)
 * @return The Newton step for updating r
 *
 * @ingroup rt_estimation
 */
real R_to_r_newton_step(real R, real r, vector pmf) {
  int len = num_elements(pmf);
  vector[len] zero_series = linspaced_vector(len, 0, len - 1);
  vector[len] exp_r = exp(-r * zero_series);
  real ret = (R * dot_product(pmf, exp_r) - 1) /
    (- R * dot_product(pmf .* zero_series, exp_r));
  return(ret);
}
 
/**
 * Estimate the growth rate r from reproduction number R
 *
 * This function uses the Newton method to solve for the growth rate r
 * that corresponds to a given reproduction number R, using the generation
 * time distribution.
 *
 * Code is based on Julia code from
 * https://github.com/CDCgov/Rt-without-renewal/blob/d6344cc6e451e3e6c4188e4984247f890ae60795/EpiAware/test/predictive_checking/fast_approx_for_r.jl
 * under Apache license 2.0.
 *
 * @param R Reproduction number
 * @param gt_rev_pmf Reversed probability mass function of the generation time
 * @param abs_tol Absolute tolerance for the Newton solver
 * @return The estimated growth rate r
 *
 * @ingroup rt_estimation
 */
real R_to_r(real R, vector gt_rev_pmf, real abs_tol) {
  int gt_len = num_elements(gt_rev_pmf);
  vector[gt_len] gt_pmf = reverse(gt_rev_pmf);
  real mean_gt = dot_product(gt_pmf, linspaced_vector(gt_len, 0, gt_len - 1));
  real r = fmax((R - 1) / (R * mean_gt), -1);
  real step = abs_tol + 1;
  while (abs(step) > abs_tol) {
    step = R_to_r_newton_step(R, r, gt_pmf);
    r -= step;
  }
 
  return(r);
}